Term	Overlap	P-value	Adjusted P-value	Old P-value	Old Adjusted P-value	Odds Ratio	Combined Score	Genes
protein binding involved in heterotypic cell-cell adhesion (GO:0086080)	4/7	1.2723738664870816E-5	0.01464502320326631	0	0	22.857142857142854	257.64665424100866	DSP;PKP2;DSG2;DSC2
cyclin-dependent protein kinase activity (GO:0097472)	6/35	2.0761786561964194E-4	0.11948408166410393	0	0	6.857142857142857	58.147277845558115	CCNA2;CCNB2;CDKN1A;CCNB1;CDK7;CDK2
type II transforming growth factor beta receptor binding (GO:0005114)	3/8	7.919445047989284E-4	0.30384270834118887	0	0	15.0	107.11528857454749	TGFB1;BAMBI;ENG
transforming growth factor beta receptor binding (GO:0005160)	6/45	8.437696124754264E-4	0.24279470598980393	0	0	5.333333333333333	37.747365715372595	TGFB1;GDF15;BAMBI;INHBA;INHA;ENG
hyaluronic acid binding (GO:0005540)	4/18	8.936428005945616E-4	0.20571657269686808	0	0	8.888888888888888	62.40181701813813	ACAN;HMMR;HAPLN3;HAPLN1
carboxylic acid transmembrane transporter activity (GO:0046943)	7/65	0.0011648599162158541	0.2234589605940747	0	0	4.3076923076923075	29.099126830462144	SLC7A5;SLC38A1;SLC43A2;SLC1A2;SLC16A12;SLC16A3;SLC16A4
cyclin-dependent protein serine/threonine kinase activity (GO:0004693)	5/34	0.0014630597586829306	0.2405688260348647	0	0	5.88235294117647	38.39544300650074	CCNB2;CDKN1A;CCNB1;CDK7;CDK2
histone kinase activity (GO:0035173)	3/10	0.0016347780174221294	0.23520368725660887	0	0	11.999999999999998	76.99497903613396	MELK;CDK2;AURKB
heme binding (GO:0020037)	7/73	0.0022984446613264304	0.29394553390963574	0	0	3.835616438356164	23.303374429050358	CYP2J2;CYP11A1;NOS3;STC2;CYP2S1;FLVCR2;CYP8B1
cadherin binding (GO:0045296)	17/314	0.002489648752489588	0.2865585714115516	0	0	2.1656050955414012	12.984131453391365	SLC3A2;ANK3;BZW2;MPP7;CCNB2;KRT18;DIAPH3;PPP1R13L;COBLL1;PKP2;PAK6;EPS8L1;STXBP6;PKP3;EZR;MB21D2;PHLDB2
neutral amino acid transmembrane transporter activity (GO:0015175)	4/25	0.0032171757921806987	0.33663357607272587	0	0	6.3999999999999995	36.731208879756906	SLC7A5;SLC38A1;SLC43A2;SLC3A2
hexose transmembrane transporter activity (GO:0015149)	3/13	0.003684485563252584	0.35340357360864366	0	0	9.23076923076923	51.72576337848703	SLC2A1;SLC2A3;MFSD4B
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (GO:0016709)	5/42	0.0037982815454921017	0.33629400452780067	0	0	4.761904761904761	26.539078759070478	SQLE;CYP11A1;NOS3;KMO;CYP8B1
protein kinase activity (GO:0004672)	23/514	0.005432679371165258	0.4466438540150866	0	0	1.7898832684824901	9.334819069959925	CDKN1A;FLT1;PNCK;MMD;CDC42BPG;HGF;HUNK;TESK2;CSF2RB;PKMYT1;PRKCZ;CSF2RA;AURKB;CCNA2;CDK7;WEE1;MELK;STK26;WNK2;CDK2;PAK6;FGFR4;EPHB3
dicarboxylic acid transmembrane transporter activity (GO:0005310)	4/29	0.005583621105065782	0.42844985946204767	0	0	5.517241379310344	28.622994590353443	SLC26A2;SLC13A3;SLC1A2;SLC26A6
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228)	15/285	0.005627829986876263	0.40485201968091117	0	0	2.1052631578947367	10.90532915501145	CEBPA;TFAP2C;HMGA1;AKR1B1;ARID3A;GATA3;FOXO4;ARID3B;GATA2;GRHL1;ETV5;MAFF;MYBL2;ATF3;ZNF750
lipoprotein particle receptor activity (GO:0030228)	3/15	0.005648024777015824	0.38240450107913015	0	0	8.0	41.41159513548328	SCARB1;LRP2;LRP8
acid-thiol ligase activity (GO:0016878)	3/16	0.006823799195615574	0.43634404856408476	0	0	7.5	37.40504171568808	ACSS1;SLC27A2;ACSF2
NADP binding (GO:0050661)	4/31	0.007112686652484723	0.430879070368943	0	0	5.161290322580645	25.527097997387994	NOS3;HSD17B1;DHCR7;TM7SF2
sequence-specific double-stranded DNA binding (GO:1990837)	8/113	0.007493428841261588	0.4312468298146044	0	0	2.831858407079646	13.858347035712622	THRB;HMGA1;NFE2L3;MCM10;PPARG;GATA3;ATF3;PPARD
nerve growth factor binding (GO:0048406)	2/6	0.0087524127649488	0.47971557583124136	0	0	13.333333333333332	63.17901162743442	FURIN;PCSK6
azole transmembrane transporter activity (GO:1901474)	2/6	0.0087524127649488	0.45791032238436674	0	0	13.333333333333332	63.17901162743442	SLC19A3;SLC19A2
monocarboxylic acid transmembrane transporter activity (GO:0008028)	4/33	0.008894984595890918	0.4451359682552368	0	0	4.848484848484849	22.89584334369705	SLC16A12;SLC16A3;SLC16A4;SLC26A6
carboxylic acid binding (GO:0031406)	4/35	0.010945733656667284	0.5249391432843352	0	0	4.571428571428571	20.639110944169403	ACAN;HMMR;HAPLN3;HAPLN1
cadherin binding involved in cell-cell adhesion (GO:0098641)	3/19	0.011170818168534696	0.5143044684793374	0	0	6.31578947368421	28.386002662889787	KRT18;PKP3;STXBP6
RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding (GO:0001133)	3/19	0.011170818168534696	0.49452352738397826	0	0	6.31578947368421	28.386002662889787	THRB;PPARG;PPARD
MAP kinase tyrosine/serine/threonine phosphatase activity (GO:0017017)	2/7	0.012051662882171474	0.5137579250881247	0	0	11.428571428571427	50.49774434338215	DUSP4;DUSP5
1-phosphatidylinositol-4-phosphate 3-kinase activity (GO:0035005)	2/7	0.012051662882171474	0.49540942776354885	0	0	11.428571428571427	50.49774434338215	PIK3CB;PIK3C2B
histone serine kinase activity (GO:0035174)	2/7	0.012051662882171474	0.47832634404756436	0	0	11.428571428571427	50.49774434338215	MELK;AURKB
steroid hydroxylase activity (GO:0008395)	4/36	0.012076117555021226	0.46332037686098104	0	0	4.444444444444444	19.629002367047192	CYP2J2;CYP11A1;CYP2S1;CYP8B1
glucose transmembrane transporter activity (GO:0005355)	3/20	0.012902143644594305	0.479044107578324	0	0	5.999999999999999	26.10217084452193	SLC2A1;SLC2A3;MFSD4B
RNA polymerase II regulatory region DNA binding (GO:0001012)	11/202	0.013007644271046004	0.46786870487418597	0	0	2.178217821782178	9.458296793734982	TFAP2C;THRB;PPARG;ARID3A;GATA3;ARID3B;GATA2;ASCL2;ATF3;ETV5;PPARD
amino acid transmembrane transporter activity (GO:0015171)	5/57	0.013793849088617314	0.4811127363938948	0	0	3.508771929824561	15.029938611919315	SLC7A5;SLC38A1;SLC43A2;SLC1A2;SLC3A2
scavenger receptor activity (GO:0005044)	3/21	0.014777987746011578	0.5002783498723331	0	0	5.7142857142857135	24.083522970404665	COLEC12;SCARB1;ACKR2
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity (GO:0004571)	2/8	0.01580491452517871	0.5197559033851626	0	0	10.0	41.47434341416576	MAN1A2;MAN1C1
type I transforming growth factor beta receptor binding (GO:0034713)	2/8	0.01580491452517871	0.5053182394022415	0	0	10.0	41.47434341416576	TGFB1;ENG
transcription regulatory region sequence-specific DNA binding (GO:0000976)	14/293	0.016070690999110245	0.49992879297232146	0	0	1.9112627986348123	7.894964288284952	TFAP2C;THRB;HMGA1;ARID3A;GATA3;ARID3B;GATA2;ASCL2;ETV5;NFE2L3;PPARG;ATF3;PPARD;ZNF750
protein binding involved in cell-cell adhesion (GO:0098632)	3/22	0.01679971420817187	0.5088545014106794	0	0	5.454545454545454	22.289418568014327	KRT18;PKP3;STXBP6
hormone activity (GO:0005179)	6/84	0.018696947110537213	0.5517996442109828	0	0	2.8571428571428568	11.369700070200947	LEP;IGF2;CGB3;INHBA;CGA;INHA
MAP kinase phosphatase activity (GO:0033549)	2/9	0.019987498286726836	0.5751402632005648	0	0	8.888888888888888	34.779095880349324	DUSP4;DUSP5
superoxide-generating NADPH oxidase activator activity (GO:0016176)	2/9	0.019987498286726836	0.56111245190299	0	0	8.888888888888888	34.779095880349324	NCF1;NCF1C
retinoid X receptor binding (GO:0046965)	2/9	0.019987498286726836	0.5477526316195854	0	0	8.888888888888888	34.779095880349324	HMGA1;PPARG
neurotrophin binding (GO:0043121)	2/9	0.019987498286726836	0.5350141983261067	0	0	8.888888888888888	34.779095880349324	FURIN;PCSK6
D-glucose transmembrane transporter activity (GO:0055056)	2/9	0.019987498286726836	0.5228547847277861	0	0	8.888888888888888	34.779095880349324	SLC2A1;SLC2A3
prostaglandin receptor activity (GO:0004955)	2/10	0.02457569018526242	0.6285915422941566	0	0	8.0	29.64798022792225	HPGD;PPARG
mannosyl-oligosaccharide mannosidase activity (GO:0015924)	2/10	0.02457569018526242	0.6149265087660227	0	0	8.0	29.64798022792225	MAN1A2;MAN1C1
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	2/10	0.02457569018526242	0.6018429660263201	0	0	8.0	29.64798022792225	PHOSPHO1;ALPL
activin binding (GO:0048185)	2/10	0.02457569018526242	0.5893045709007718	0	0	8.0	29.64798022792225	FSTL3;ENG
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity (GO:0008532)	2/10	0.02457569018526242	0.5772779470048377	0	0	8.0	29.64798022792225	B3GNT5;B3GNT3
cyclin-dependent protein serine/threonine kinase inhibitor activity (GO:0004861)	2/10	0.02457569018526242	0.5657323880647409	0	0	8.0	29.64798022792225	HEXIM1;CDKN1A
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (GO:0016620)	3/26	0.026359322007969647	0.5948937182582954	0	0	4.615384615384615	16.781230569993895	ALDH4A1;ALDH3B2;FAR2
regulatory region DNA binding (GO:0000975)	11/225	0.02652924462368878	0.5872146261897266	0	0	1.9555555555555555	7.097703719374876	CEBPA;HDAC5;MSX2;AKR1B1;PPARG;MYBL2;GATA3;GRHL1;ATF3;ETV5;TEAD3
DNA binding (GO:0003677)	32/894	0.027050941190507344	0.5874647794391312	0	0	1.4317673378076061	5.168728024800345	CEBPA;THRB;AKR1B1;HMGB3;MCM10;MLLT1;GATA3;FOXO4;EXO1;MYBL2;TEAD3;CDT1;TFAP2C;MSX2;HMGA1;TET1;ARID3B;GRHL1;TBX3;HIST2H2BE;ETV5;HIC2;MYCL;RAD51;NR6A1;MAFF;FOSB;PPARG;MAFK;PPARD;MCM2;HIST1H2BC
transcription regulatory region DNA binding (GO:0044212)	16/375	0.02728976156193527	0.5816762140331018	0	0	1.7066666666666666	6.146122549752392	CEBPA;HDAC5;TFAP2C;THRB;MSX2;AKR1B1;GATA3;GRHL1;ASCL2;ETV5;NFE2L3;PPARG;MYBL2;ATF3;TEAD3;PPARD
growth factor activity (GO:0008083)	5/70	0.03071766872573008	0.6428370309693695	0	0	2.8571428571428568	9.951192175476	HGF;IGF2;INHBA;INHA;PGF
cyclin-dependent protein serine/threonine kinase regulator activity (GO:0016538)	3/28	0.03202293203002463	0.6581856208313992	0	0	4.285714285714286	14.748441458133852	HEXIM1;CDKN1A;CCNB1
protein tyrosine kinase activity (GO:0004713)	8/148	0.0327582758890953	0.6614872903219069	0	0	2.1621621621621623	7.391566810638256	WEE1;MELK;FLT1;HGF;CSF2RB;FGFR4;CSF2RA;EPHB3
oxalate transmembrane transporter activity (GO:0019531)	2/12	0.03487854042134841	0.6921586211202072	0	0	6.666666666666666	22.372556843567576	SLC26A2;SLC26A6
sodium:amino acid symporter activity (GO:0005283)	2/12	0.03487854042134841	0.6804271190673223	0	0	6.666666666666666	22.372556843567576	SLC38A1;SLC1A2
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity (GO:0052629)	2/12	0.03487854042134841	0.669086667082867	0	0	6.666666666666666	22.372556843567576	SYNJ1;MTMR4
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity (GO:0008499)	2/12	0.03487854042134841	0.6581180331962626	0	0	6.666666666666666	22.372556843567576	B3GNT5;B3GNT3
oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor (GO:0050664)	2/12	0.03487854042134841	0.6475032262092262	0	0	6.666666666666666	22.372556843567576	NCF1;KMO
sulfate transmembrane transporter activity (GO:0015116)	2/12	0.03487854042134841	0.6372253972217781	0	0	6.666666666666666	22.372556843567576	SLC26A2;SLC26A6
CoA-ligase activity (GO:0016405)	2/12	0.03487854042134841	0.6272687503901878	0	0	6.666666666666666	22.372556843567576	ACSS1;ACSF2
L-amino acid transmembrane transporter activity (GO:0015179)	4/50	0.036004517553649654	0.6375569185269346	0	0	3.1999999999999997	10.637154754552185	SLC7A5;SLC38A1;SLC43A2;SLC1A2
organic acid:sodium symporter activity (GO:0005343)	2/13	0.040550197611673826	0.7071708704702512	0	0	6.153846153846154	19.724397693220933	SLC13A3;SLC38A1
low-density lipoprotein receptor activity (GO:0005041)	2/13	0.040550197611673826	0.6966160813587549	0	0	6.153846153846154	19.724397693220933	LRP2;LRP8
protein serine/threonine kinase inhibitor activity (GO:0030291)	3/31	0.04160691113161275	0.704258157536563	0	0	3.8709677419354835	12.307699325969082	HEXIM1;PKIB;CDKN1A
protein serine/threonine kinase activity (GO:0004674)	15/369	0.045440348466512376	0.7579976968834167	0	0	1.6260162601626016	5.02659322907542	CDKN1A;PNCK;CDC42BPG;HUNK;TESK2;PRKCZ;AURKB;CCNB2;CCNB1;CDK7;MELK;WNK2;STK26;CDK2;PAK6
phosphatidylinositol monophosphate phosphatase activity (GO:0052744)	2/14	0.04654140207685347	0.7652736255779763	0	0	5.7142857142857135	17.52807425877975	SYNJ1;MTMR4
beta-1,3-galactosyltransferase activity (GO:0048531)	2/14	0.04654140207685347	0.7544951238092724	0	0	5.7142857142857135	17.52807425877975	B3GNT5;B3GNT3
1-phosphatidylinositol binding (GO:0005545)	2/14	0.04654140207685347	0.744016024867477	0	0	5.7142857142857135	17.52807425877975	SCARB1;SCIN
phosphatidylinositol-3-phosphatase activity (GO:0004438)	2/14	0.04654140207685347	0.7338240245268266	0	0	5.7142857142857135	17.52807425877975	SYNJ1;MTMR4
phosphatidylinositol-3,5-bisphosphate phosphatase activity (GO:0106018)	2/15	0.05283270093282616	0.8217626861308501	0	0	5.333333333333333	15.683333035361262	SYNJ1;MTMR4
phosphatidylinositol phosphate kinase activity (GO:0016307)	2/15	0.05283270093282616	0.8108058503157721	0	0	5.333333333333333	15.683333035361262	PIK3CB;PIK3C2B
5'-3' exonuclease activity (GO:0008409)	2/15	0.05283270093282616	0.8001373522853015	0	0	5.333333333333333	15.683333035361262	EXO1;DCP2
chloride transmembrane transporter activity (GO:0015108)	4/57	0.05400611450011817	0.807286205060208	0	0	2.807017543859649	8.192724231142156	CLIC5;SLC26A2;CLIC3;SLC26A6
cytokine receptor binding (GO:0005126)	7/138	0.058456240913430456	0.8626042729661341	0	0	2.028985507246377	5.761257322482767	TGFB1;GDF15;CCRL2;LIFR;INHBA;INHA;PGF
retinoic acid receptor binding (GO:0042974)	2/16	0.05940541077305161	0.8655142759466128	0	0	5.0	14.116849831533036	HMGA1;PPARG
four-way junction DNA binding (GO:0000400)	2/16	0.05940541077305161	0.85469534749728	0	0	5.0	14.116849831533036	RAD51;HMGB3
arachidonic acid monooxygenase activity (GO:0008391)	2/17	0.0662415915707929	0.9412848382466992	0	0	4.705882352941176	12.773867020503221	CYP2J2;CYP2S1
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor (GO:0016628)	2/17	0.0662415915707929	0.9298057548534467	0	0	4.705882352941176	12.773867020503221	DHCR7;TM7SF2
arachidonic acid epoxygenase activity (GO:0008392)	2/17	0.0662415915707929	0.9186032758793089	0	0	4.705882352941176	12.773867020503221	CYP2J2;CYP2S1
low-density lipoprotein particle binding (GO:0030169)	2/17	0.0662415915707929	0.9076675225950314	0	0	4.705882352941176	12.773867020503221	COLEC12;SCARB1
chloride channel activity (GO:0005254)	4/62	0.06934618550712146	0.9390289355140801	0	0	2.5806451612903225	6.886823579964537	CLIC5;SLC26A2;CLIC3;SLC26A6
phosphatidylinositol bisphosphate binding (GO:1902936)	5/88	0.06959641390380192	0.931458981433442	0	0	2.2727272727272725	6.056914175772388	SCIN;NCF1;NCF1C;STXBP6;SYT7
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	17/461	0.07259301227604135	0.9603972083876277	0	0	1.4750542299349239	3.868899990822102	TFAP2C;THRB;AKR1B1;ARID3A;GATA3;ARID3B;GATA2;GRHL1;ASCL2;TBX3;ETV5;NR6A1;FOSB;PPARG;MYBL2;ATF3;PPARD
ion antiporter activity (GO:0099516)	2/18	0.07332402120449992	0.9590448682543115	0	0	4.444444444444444	11.612742279715478	SLC26A2;SLC26A6
semaphorin receptor binding (GO:0030215)	2/18	0.07332402120449992	0.9482690832177461	0	0	4.444444444444444	11.612742279715478	SEMA7A;SEMA3B
lysophospholipase activity (GO:0004622)	2/19	0.08063617099611983	1.0	0	0	4.2105263157894735	10.601296667256518	GDPD1;PLBD1
neuropilin binding (GO:0038191)	2/19	0.08063617099611983	1.0	0	0	4.2105263157894735	10.601296667256518	SEMA7A;SEMA3B
spectrin binding (GO:0030507)	2/19	0.08063617099611983	1.0	0	0	4.2105263157894735	10.601296667256518	MYO7A;ANK3
protein kinase C binding (GO:0005080)	3/41	0.08241355278955437	1.0	0	0	2.9268292682926824	7.305381599970589	DSP;HDAC5;PKP2
ligand-dependent nuclear receptor transcription coactivator activity (GO:0030374)	4/66	0.08305732510112497	1.0	0	0	2.4242424242424243	6.03205877749113	THRB;HMGA1;PPARG;PPARD
RNA polymerase II transcription factor binding (GO:0001085)	6/122	0.085840049639565	1.0	0	0	1.9672131147540983	4.830038562058518	HDAC5;AKR1B1;GATA3;GATA2;TBX3;TEAD3
anion channel activity (GO:0005253)	4/67	0.08667836668553372	1.0	0	0	2.388059701492537	5.840121660964135	CLIC5;SLC26A2;CLIC3;SLC26A6
pyrophosphatase activity (GO:0016462)	3/42	0.08718222910547488	1.0	0	0	2.8571428571428568	6.970727895708977	PHOSPHO1;ALPL;DCP2
androgen receptor binding (GO:0050681)	3/43	0.0920646511043347	1.0	0	0	2.7906976744186043	6.656551309777228	GRIP1;CDK7;CCNE1
peptidase activity, acting on L-amino acid peptides (GO:0070011)	8/186	0.09581214062161766	1.0	0	0	1.7204301075268817	4.035038061432835	ADAM12;HTRA4;GGH;FURIN;PRSS8;CTSV;PCSK6;TRABD2A
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0033764)	2/21	0.09588684119947874	1.0	0	0	3.8095238095238093	8.931758172484527	HSD11B2;HSD17B1
anion:anion antiporter activity (GO:0015301)	2/21	0.09588684119947874	1.0	0	0	3.8095238095238093	8.931758172484527	SLC26A2;SLC26A6
chemokine receptor activity (GO:0004950)	2/21	0.09588684119947874	1.0	0	0	3.8095238095238093	8.931758172484527	CCR7;ACKR2
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (GO:0016712)	2/21	0.09588684119947874	1.0	0	0	3.8095238095238093	8.931758172484527	CYP2J2;CYP2S1
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0000982)	11/281	0.09608952282658934	1.0	0	0	1.5658362989323842	3.6679323727640303	TFAP2C;SNAI1;AKR1B1;FOSB;MYBL2;GATA3;GRHL1;ASCL2;ATF3;TBX3;ZNF750
kinase activity (GO:0016301)	11/281	0.09608952282658934	1.0	0	0	1.5658362989323842	3.6679323727640303	CDK7;WEE1;MMD;CKMT1A;STK26;CDK2;TESK2;PIK3CB;PKMYT1;PRKCZ;PIK3C2B
anion:cation symporter activity (GO:0015296)	3/44	0.09705771960273352	1.0	0	0	2.727272727272727	6.361225718177528	SLC13A3;SLC13A4;SLC1A2
1-phosphatidylinositol-3-kinase activity (GO:0016303)	3/44	0.09705771960273352	1.0	0	0	2.727272727272727	6.361225718177528	PIK3CB;FGFR4;PIK3C2B
core promoter binding (GO:0001047)	5/98	0.09918802730486051	1.0	0	0	2.0408163265306123	4.71579176421747	HDAC5;TFAP2C;PPARG;GATA3;ZNF750
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001078)	5/98	0.09918802730486051	1.0	0	0	2.0408163265306123	4.71579176421747	TFAP2C;SNAI1;GATA3;ASCL2;TBX3
solute:sodium symporter activity (GO:0015370)	2/22	0.10379556080326813	1.0	0	0	3.6363636363636362	8.237571185428129	SLC5A6;SLC1A2
bicarbonate transmembrane transporter activity (GO:0015106)	2/22	0.10379556080326813	1.0	0	0	3.6363636363636362	8.237571185428129	SLC26A2;SLC26A6
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism (GO:0015662)	2/22	0.10379556080326813	1.0	0	0	3.6363636363636362	8.237571185428129	ATP7B;ATP6V1C2
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001227)	7/160	0.10718169922556198	1.0	0	0	1.7499999999999998	3.90815208192248	TFAP2C;SNAI1;MAFK;GATA3;ASCL2;TBX3;PPARD
exopeptidase activity (GO:0008238)	3/46	0.10736313441562158	1.0	0	0	2.6086956521739126	5.821404549935052	CPM;DPEP2;GGH
tubulin binding (GO:0015631)	10/256	0.11009018495344683	1.0	0	0	1.5625	3.4475865404387926	BEX4;REEP1;PSRC1;BIRC5;EZR;FAM83D;KIF17;CCSAP;S100A9;RAB11FIP5
lipoprotein particle binding (GO:0071813)	2/23	0.11187435504137663	1.0	0	0	3.4782608695652173	7.618709103989623	COLEC12;SCARB1
cytokine receptor activity (GO:0004896)	4/74	0.11407613801901988	1.0	0	0	2.1621621621621623	4.693814434937615	EBI3;LIFR;CSF2RB;ACKR2
microtubule binding (GO:0008017)	8/196	0.11941648283430593	1.0	0	0	1.6326530612244896	3.469613127122905	REEP1;PSRC1;BIRC5;EZR;FAM83D;KIF17;CCSAP;S100A9
G-protein coupled receptor binding (GO:0001664)	6/134	0.11992924955826728	1.0	0	0	1.7910447761194028	3.7985432186674037	REEP1;BAMBI;ITGB4;CCRL2;AGTR1;ADM
phosphatidylinositol 3-kinase activity (GO:0035004)	4/77	0.12685161688191973	1.0	0	0	2.0779220779220777	4.290363109838066	HGF;PIK3CB;FGFR4;PIK3C2B
steroid hormone receptor binding (GO:0035258)	4/77	0.12685161688191973	1.0	0	0	2.0779220779220777	4.290363109838066	GRIP1;CDK7;CCNE1;LRP2
UDP-galactosyltransferase activity (GO:0035250)	2/25	0.12848911332067864	1.0	0	0	3.1999999999999997	6.566115518322446	B3GNT5;B3GNT3
DNA secondary structure binding (GO:0000217)	2/25	0.12848911332067864	1.0	0	0	3.1999999999999997	6.566115518322446	RAD51;HMGB3
phosphatidylinositol-3,4-bisphosphate binding (GO:0043325)	2/25	0.12848911332067864	1.0	0	0	3.1999999999999997	6.566115518322446	NCF1;NCF1C
acetylglucosaminyltransferase activity (GO:0008375)	3/51	0.13483744322316818	1.0	0	0	2.352941176470588	4.714553765545066	HEXB;B3GNT5;B3GNT3
actin monomer binding (GO:0003785)	2/26	0.1369999344737361	1.0	0	0	3.076923076923077	6.116230250609304	NOS3;COBLL1
SH3/SH2 adaptor activity (GO:0005070)	3/52	0.14059914501552925	1.0	0	0	2.3076923076923075	4.527328570603137	BCAR3;VAV3;SH2B2
phosphatidylinositol kinase activity (GO:0052742)	3/52	0.14059914501552925	1.0	0	0	2.3076923076923075	4.527328570603137	PIK3CB;FGFR4;PIK3C2B
7SK snRNA binding (GO:0097322)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	HEXIM1
patched binding (GO:0005113)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	CCNB1
clathrin light chain binding (GO:0032051)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	NSG1
long-chain fatty acid binding (GO:0036041)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	PPARD
prostaglandin E receptor activity (GO:0004957)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	HPGD
cation:amino acid symporter activity (GO:0005416)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	SLC38A1
calcium:sodium antiporter activity (GO:0005432)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	SLC3A2
NADPH-hemoprotein reductase activity (GO:0003958)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	NOS3
ADP-ribosylation factor binding (GO:0030306)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	RAB11FIP4
peptidyl-proline 4-dioxygenase activity (GO:0031545)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	EGLN3
NAD(P)H oxidase activity (GO:0016174)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	KMO
olfactory receptor binding (GO:0031849)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	REEP1
arylesterase activity (GO:0004064)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	CA2
arginine binding (GO:0034618)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	NOS3
5'-3' exodeoxyribonuclease activity (GO:0035312)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	EXO1
peroxisome proliferator activated receptor binding (GO:0042975)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	HMGA1
phosphatidylinositol phosphate phosphatase activity (GO:0052866)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	SYNJ1
T cell receptor binding (GO:0042608)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	EPS8L1
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides (GO:0016812)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	CPS1
exoribonuclease activity (GO:0004532)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	DCP2
aldehyde dehydrogenase [NAD(P)+] activity (GO:0004030)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	ALDH3B2
LBD domain binding (GO:0050693)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	PPARG
very long-chain fatty acid-CoA ligase activity (GO:0031957)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	SLC27A2
enhancer binding (GO:0035326)	2/27	0.1456305058632748	1.0	0	0	2.962962962962963	5.708689324070283	HMGA1;GATA2
collagen binding (GO:0005518)	3/53	0.14644202157094957	1.0	0	0	2.2641509433962264	4.349718534458366	PCOLCE2;ADGRG6;FN1
iron ion binding (GO:0005506)	3/55	0.15835797713897543	1.0	0	0	2.1818181818181817	4.020866466848246	SCD;FDX1;TET1
high-affinity glutamate transmembrane transporter activity (GO:0005314)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	SLC1A2
AT DNA binding (GO:0003680)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	HMGA1
satellite DNA binding (GO:0003696)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	HEY1
omega peptidase activity (GO:0008242)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	GGH
superoxide-generating NADPH oxidase activity (GO:0016175)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	NCF1
estradiol 17-beta-dehydrogenase activity (GO:0004303)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	HSD17B1
fatty acid elongase activity (GO:0009922)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	ELOVL2
flap endonuclease activity (GO:0048256)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	EXO1
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity (GO:0052659)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	SYNJ1
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity (GO:0003836)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	ST3GAL4
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (GO:0016713)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	CYP11A1
peptidyl-proline dioxygenase activity (GO:0031543)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	EGLN3
C4-dicarboxylate transmembrane transporter activity (GO:0015556)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	SLC13A3
phosphatidylinositol phosphate 4-phosphatase activity (GO:0034596)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	SYNJ1
vascular endothelial growth factor-activated receptor activity (GO:0005021)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	FLT1
single-stranded DNA exodeoxyribonuclease activity (GO:0008297)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	EXO1
phosphoric ester hydrolase activity (GO:0042578)	3/57	0.1705587717216263	1.0	0	0	2.1052631578947367	3.723527030473866	DUSP4;DUSP5;PHOSPHO1
nuclear hormone receptor binding (GO:0035257)	3/57	0.1705587717216263	1.0	0	0	2.1052631578947367	3.723527030473866	HMGA1;LRP2;TACC2
calcium ion binding (GO:0005509)	10/285	0.17845422001013414	1.0	0	0	1.4035087719298245	2.4188395525446955	MELK;SCUBE1;SCIN;SELL;MAN1C1;LRP2;SLIT2;S100A9;SYT7;CD320
NEDD8-specific protease activity (GO:0019784)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	OTUB2
3-chloroallyl aldehyde dehydrogenase activity (GO:0004028)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	ALDH3B2
C-C chemokine binding (GO:0019957)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	CCR7
acyl-CoA ligase activity (GO:0003996)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	ACSF2
phosphofructokinase activity (GO:0008443)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	PFKFB4
m7G(5')pppN diphosphatase activity (GO:0050072)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	DCP2
activin receptor binding (GO:0070697)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	INHBA
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity (GO:0004439)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	SYNJ1
phosphatidylcholine transporter activity (GO:0008525)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	ABCB1
epinephrine binding (GO:0051379)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	ADRB1
transcription factor activity, RNA polymerase II transcription factor recruiting (GO:0001135)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	MYBL2
lipoprotein lipase activity (GO:0004465)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	LIPG
NAD+ binding (GO:0070403)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	HPGD
phosphatidylinositol-4,5-bisphosphate phosphatase activity (GO:0106019)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	SYNJ1
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	9/255	0.19017510175007976	1.0	0	0	1.4117647058823528	2.3432612372681985	CDK7;MMD;STK26;TESK2;PIK3CB;PKMYT1;PRKCZ;HK2;PIK3C2B
protein serine/threonine kinase activator activity (GO:0043539)	2/32	0.1902017379712103	1.0	0	0	2.5	4.149174978285558	CCNB1;IGF2
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (GO:0016706)	2/32	0.1902017379712103	1.0	0	0	2.5	4.149174978285558	EGLN3;TET1
phosphatidylinositol-4,5-bisphosphate binding (GO:0005546)	3/61	0.19571013951815233	1.0	0	0	1.9672131147540983	3.2087618250165857	SCIN;STXBP6;SYT7
transcription coactivator activity (GO:0003713)	10/292	0.19740082125074546	1.0	0	0	1.36986301369863	2.2226287556894344	GRIP1;CEBPA;CDK7;THRB;CCNE1;HMGA1;NFE2L3;PPARG;GATA3;PPARD
transition metal ion transmembrane transporter activity (GO:0046915)	2/33	0.19933052198776197	1.0	0	0	2.4242424242424243	3.9097961637318743	ATP7B;SLC39A8
transmembrane receptor protein tyrosine kinase activity (GO:0004714)	3/62	0.20213542656566247	1.0	0	0	1.9354838709677418	3.0944852471126474	FLT1;FGFR4;EPHB3
serine-type exopeptidase activity (GO:0070008)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	CPM
GABA receptor binding (GO:0050811)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	PLCL2
hydrogen-exporting ATPase activity, phosphorylative mechanism (GO:0008553)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	ATP6V1C2
RAGE receptor binding (GO:0050786)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	S100A9
UDP-glucosyltransferase activity (GO:0035251)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	GYG2
dolichyl-diphosphooligosaccharide-protein glycotransferase activity (GO:0004579)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	TUSC3
Toll-like receptor binding (GO:0035325)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	S100A9
serine-type carboxypeptidase activity (GO:0004185)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	CPM
peptide disulfide oxidoreductase activity (GO:0015037)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	GLRX
BMP binding (GO:0036122)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	ENG
cytidylyltransferase activity (GO:0070567)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	CMAS
glucocorticoid receptor binding (GO:0035259)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	GRIP1
inositol tetrakisphosphate phosphatase activity (GO:0052743)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	SYNJ1
cAMP-dependent protein kinase inhibitor activity (GO:0004862)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	PKIB
transmembrane receptor protein kinase activity (GO:0019199)	3/63	0.20860938631238252	1.0	0	0	1.9047619047619047	2.985317601379297	FLT1;FGFR4;EPHB3
integrin binding (GO:0005178)	4/95	0.21407627612000896	1.0	0	0	1.6842105263157894	2.5960806686302367	SEMA7A;COL16A1;EGFL6;FN1
UDP-glycosyltransferase activity (GO:0008194)	3/64	0.21512892953081966	1.0	0	0	1.875	2.8809707969055927	HEXB;B3GNT5;B3GNT3
actin filament binding (GO:0051015)	5/128	0.2170847599208247	1.0	0	0	1.5625	2.3866678171750295	SCIN;NEBL;CORO6;MYO7A;EZR
protein tyrosine/serine/threonine phosphatase activity (GO:0008138)	2/35	0.21773131350006625	1.0	0	0	2.2857142857142856	3.484556533108	DUSP4;DUSP5
E-box binding (GO:0070888)	2/35	0.21773131350006625	1.0	0	0	2.2857142857142856	3.484556533108	GATA3;ASCL2
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding (GO:0003705)	3/65	0.2216910070831208	1.0	0	0	1.8461538461538463	2.7811767260910543	CEBPA;HMGA1;VGLL3
Lys48-specific deubiquitinase activity (GO:1990380)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	USP27X
protein serine/threonine phosphatase inhibitor activity (GO:0004865)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	PPP1R14C
endocytic adaptor activity (GO:0098748)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	DAB2
oligosaccharyl transferase activity (GO:0004576)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	TUSC3
exodeoxyribonuclease activity, producing 5'-phosphomonoesters (GO:0016895)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	EXO1
carbon-nitrogen ligase activity, with glutamine as amido-N-donor (GO:0016884)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	CPS1
protein kinase C activity (GO:0004697)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	PRKCZ
phosphatidylcholine 1-acylhydrolase activity (GO:0008970)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	LIPG
clathrin adaptor activity (GO:0035615)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	DAB2
long-chain fatty acid-CoA ligase activity (GO:0004467)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	SLC27A2
dipeptidase activity (GO:0016805)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	DPEP2
fatty acid synthase activity (GO:0004312)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	ELOVL2
vascular endothelial growth factor receptor binding (GO:0005172)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	PGF
inositol trisphosphate phosphatase activity (GO:0046030)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	SYNJ1
magnesium ion transmembrane transporter activity (GO:0015095)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	TUSC3
endodeoxyribonuclease activity (GO:0004520)	2/36	0.22698728149273847	1.0	0	0	2.222222222222222	3.2952473149705526	RAD51;EXO1
mitogen-activated protein kinase kinase binding (GO:0031434)	3/66	0.22829261173331122	1.0	0	0	1.8181818181818181	2.685685614666917	FLT1;FGFR4;EPHB3
metalloendopeptidase activity (GO:0004222)	3/66	0.22829261173331122	1.0	0	0	1.8181818181818181	2.685685614666917	MMP11;MMP15;TRABD2A
secondary active transmembrane transporter activity (GO:0015291)	3/67	0.23493078009641188	1.0	0	0	1.7910447761194028	2.594264527179215	SLC7A5;SLC19A1;SLC26A6
peptidase inhibitor activity (GO:0030414)	2/37	0.2362702199007159	1.0	0	0	2.1621621621621623	3.1195224419228023	GPC3;TFPI
double-stranded DNA binding (GO:0003690)	4/100	0.24076340791661854	1.0	0	0	1.5999999999999999	2.2783048601180695	RAD51;HMGB3;MCM10;PPARG
filamin binding (GO:0031005)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	NEBL
peptide hormone receptor binding (GO:0051428)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	LEP
gap junction channel activity (GO:0005243)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	GJA5
hexosaminidase activity (GO:0015929)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	HEXB
microtubule-severing ATPase activity (GO:0008568)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	FIGN
Lys63-specific deubiquitinase activity (GO:0061578)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	USP27X
intramolecular transferase activity, phosphotransferases (GO:0016868)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	BPGM
intermediate filament binding (GO:0019215)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	PKP2
MAP kinase kinase kinase kinase activity (GO:0008349)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	STK26
2 iron, 2 sulfur cluster binding (GO:0051537)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	FDX1
phosphatidylinositol binding (GO:0035091)	4/101	0.24619177364498787	1.0	0	0	1.584158415841584	2.220426897571902	SCARB1;SCIN;NCF1;NCF1C
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)	3/69	0.24830518328238543	1.0	0	0	1.7391304347826086	2.4227768897492368	HGF;PIK3CB;FGFR4
divalent inorganic cation transmembrane transporter activity (GO:0072509)	2/39	0.25488887753083794	1.0	0	0	2.051282051282051	2.8039540578253006	TUSC3;SLC39A8
phospholipase activity (GO:0004620)	3/70	0.2550357246055415	1.0	0	0	1.7142857142857142	2.342317109389694	LIPG;GDPD1;PLBD1
metallopeptidase activity (GO:0008237)	4/103	0.2571271620434609	1.0	0	0	1.553398058252427	2.1098012000212023	MMP11;MMP15;ADAM12;TRABD2A
phosphoprotein phosphatase activity (GO:0004721)	5/137	0.2587049099112584	1.0	0	0	1.45985401459854	1.97382074569392	DUSP4;DUSP5;MTMR4;CDC25A;PTPRF
protein kinase binding (GO:0019901)	15/496	0.2613555513048762	1.0	0	0	1.2096774193548387	1.6232341127000711	DSP;HDAC5;ERRFI1;CDKN1A;FLT1;CDC25A;RHOBTB1;CCNA2;TRIM6;CCNB1;PKP2;EZR;FAM83D;FGFR4;EPHB3
calcium:cation antiporter activity (GO:0015368)	1/12	0.26206365162305645	1.0	0	0	3.333333333333333	4.463892865337529	SLC3A2
BMP receptor binding (GO:0070700)	1/12	0.26206365162305645	1.0	0	0	3.333333333333333	4.463892865337529	TGFB1
wide pore channel activity (GO:0022829)	1/12	0.26206365162305645	1.0	0	0	3.333333333333333	4.463892865337529	GJA5
C2H2 zinc finger domain binding (GO:0070742)	1/12	0.26206365162305645	1.0	0	0	3.333333333333333	4.463892865337529	GATA2
DNA-(apurinic or apyrimidinic site) lyase activity (GO:0003906)	1/12	0.26206365162305645	1.0	0	0	3.333333333333333	4.463892865337529	HMGA1
DNA replication origin binding (GO:0003688)	1/12	0.26206365162305645	1.0	0	0	3.333333333333333	4.463892865337529	MCM10
single-stranded DNA-dependent ATPase activity (GO:0043142)	1/12	0.26206365162305645	1.0	0	0	3.333333333333333	4.463892865337529	RAD51
alditol:NADP+ 1-oxidoreductase activity (GO:0004032)	1/12	0.26206365162305645	1.0	0	0	3.333333333333333	4.463892865337529	AKR1B1
carboxylic ester hydrolase activity (GO:0052689)	4/104	0.26263115463910613	1.0	0	0	1.5384615384615385	2.056930284626031	CA2;LIPG;GDPD1;PLBD1
core promoter proximal region sequence-specific DNA binding (GO:0000987)	9/279	0.2649789309834774	1.0	0	0	1.2903225806451613	1.713683821779857	NR6A1;AKR1B1;FOSB;MYBL2;GATA3;GRHL1;ASCL2;ATF3;TBX3
phosphatase activity (GO:0016791)	4/105	0.2681573440683617	1.0	0	0	1.523809523809524	2.005609700597553	DUSP4;DUSP5;PHOSPHO1;CDC25A
phosphatidylinositol bisphosphate kinase activity (GO:0052813)	3/72	0.2685696227705788	1.0	0	0	1.6666666666666665	2.1910751599377134	HGF;PIK3CB;FGFR4
hormone receptor binding (GO:0051427)	2/41	0.2735343283108339	1.0	0	0	1.951219512195122	2.529420780778097	LEP;TACC2
carbohydrate kinase activity (GO:0019200)	1/13	0.28052310882224873	1.0	0	0	3.076923076923077	3.911074378522308	HK2
insulin-like growth factor I binding (GO:0031994)	1/13	0.28052310882224873	1.0	0	0	3.076923076923077	3.911074378522308	ITGB4
protein kinase A catalytic subunit binding (GO:0034236)	1/13	0.28052310882224873	1.0	0	0	3.076923076923077	3.911074378522308	EZR
phosphatidylinositol phosphate 5-phosphatase activity (GO:0034595)	1/13	0.28052310882224873	1.0	0	0	3.076923076923077	3.911074378522308	SYNJ1
GTPase inhibitor activity (GO:0005095)	1/13	0.28052310882224873	1.0	0	0	3.076923076923077	3.911074378522308	SLIT2
acidic amino acid transmembrane transporter activity (GO:0015172)	1/13	0.28052310882224873	1.0	0	0	3.076923076923077	3.911074378522308	SLC1A2
oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor (GO:0016653)	1/13	0.28052310882224873	1.0	0	0	3.076923076923077	3.911074378522308	NOS3
G-protein coupled photoreceptor activity (GO:0008020)	1/13	0.28052310882224873	1.0	0	0	3.076923076923077	3.911074378522308	OPN3
carbonate dehydratase activity (GO:0004089)	1/13	0.28052310882224873	1.0	0	0	3.076923076923077	3.911074378522308	CA2
core promoter sequence-specific DNA binding (GO:0001046)	3/74	0.28218271785894006	1.0	0	0	1.6216216216216217	2.051676457611424	PPARG;GATA3;ZNF750
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (GO:0016820)	2/43	0.2921586298875362	1.0	0	0	1.8604651162790697	2.2892248766192735	ABCB1;ABCG2
tropomyosin binding (GO:0005523)	1/14	0.29852170306951037	1.0	0	0	2.8571428571428568	3.4540361191199316	NEBL
insulin-like growth factor binding (GO:0005520)	1/14	0.29852170306951037	1.0	0	0	2.8571428571428568	3.4540361191199316	ITGB4
lipoprotein transporter activity (GO:0042954)	1/14	0.29852170306951037	1.0	0	0	2.8571428571428568	3.4540361191199316	LRP2
Rac guanyl-nucleotide exchange factor activity (GO:0030676)	1/14	0.29852170306951037	1.0	0	0	2.8571428571428568	3.4540361191199316	EPS8L1
aldehyde dehydrogenase (NAD) activity (GO:0004029)	1/14	0.29852170306951037	1.0	0	0	2.8571428571428568	3.4540361191199316	ALDH4A1
heparan sulfate sulfotransferase activity (GO:0034483)	1/14	0.29852170306951037	1.0	0	0	2.8571428571428568	3.4540361191199316	HS6ST2
L-glutamate transmembrane transporter activity (GO:0005313)	1/14	0.29852170306951037	1.0	0	0	2.8571428571428568	3.4540361191199316	SLC1A2
nucleoside kinase activity (GO:0019206)	1/14	0.29852170306951037	1.0	0	0	2.8571428571428568	3.4540361191199316	TK1
potassium channel regulator activity (GO:0015459)	2/44	0.30144914903771564	1.0	0	0	1.8181818181818181	2.180279885359369	RASA1;KCNS3
actin binding (GO:0003779)	8/255	0.307283664792711	1.0	0	0	1.2549019607843137	1.4807641957116362	SCIN;NEBL;NOS3;COBLL1;CORO6;EPS8L1;MYO7A;EZR
endopeptidase inhibitor activity (GO:0004866)	4/112	0.30733899532659725	1.0	0	0	1.4285714285714284	1.6854341732739702	SERPINE2;BIRC5;FURIN;TFPI
protein serine/threonine/tyrosine kinase activity (GO:0004712)	1/15	0.3160709178495968	1.0	0	0	2.6666666666666665	3.0714364453326795	AURKB
protein disulfide oxidoreductase activity (GO:0015035)	1/15	0.3160709178495968	1.0	0	0	2.6666666666666665	3.0714364453326795	GLRX
adrenergic receptor binding (GO:0031690)	1/15	0.3160709178495968	1.0	0	0	2.6666666666666665	3.0714364453326795	ADRB1
RNA polymerase II carboxy-terminal domain kinase activity (GO:0008353)	1/15	0.3160709178495968	1.0	0	0	2.6666666666666665	3.0714364453326795	CDK7
myosin V binding (GO:0031489)	1/15	0.3160709178495968	1.0	0	0	2.6666666666666665	3.0714364453326795	RAB3B
transmembrane receptor protein tyrosine phosphatase activity (GO:0005001)	1/15	0.3160709178495968	1.0	0	0	2.6666666666666665	3.0714364453326795	PTPRF
transmembrane receptor protein phosphatase activity (GO:0019198)	1/15	0.3160709178495968	1.0	0	0	2.6666666666666665	3.0714364453326795	PTPRF
insulin-like growth factor receptor binding (GO:0005159)	1/15	0.3160709178495968	1.0	0	0	2.6666666666666665	3.0714364453326795	IGF2
MAP kinase kinase kinase activity (GO:0004709)	3/79	0.3164279982103083	1.0	0	0	1.5189873417721518	1.747837301901023	FLT1;FGFR4;EPHB3
ATPase activity, coupled to transmembrane movement of substances (GO:0042626)	2/46	0.3199619156443703	1.0	0	0	1.7391304347826086	1.981831832838938	ABCB1;ABCG2
P-P-bond-hydrolysis-driven transmembrane transporter activity (GO:0015405)	2/46	0.3199619156443703	1.0	0	0	1.7391304347826086	1.981831832838938	ABCB1;ABCG2
G-protein coupled chemoattractant receptor activity (GO:0001637)	1/16	0.33318195100730313	1.0	0	0	2.5	2.7476663470054308	ACKR2
potassium ion leak channel activity (GO:0022841)	1/16	0.33318195100730313	1.0	0	0	2.5	2.7476663470054308	KCNK5
peptidase activator activity (GO:0016504)	1/16	0.33318195100730313	1.0	0	0	2.5	2.7476663470054308	PCOLCE2
sulfuric ester hydrolase activity (GO:0008484)	1/16	0.33318195100730313	1.0	0	0	2.5	2.7476663470054308	STS
transmembrane receptor protein serine/threonine kinase binding (GO:0070696)	1/16	0.33318195100730313	1.0	0	0	2.5	2.7476663470054308	TGFB1
DNA polymerase binding (GO:0070182)	1/16	0.33318195100730313	1.0	0	0	2.5	2.7476663470054308	RAD51
adrenergic receptor activity (GO:0004935)	1/16	0.33318195100730313	1.0	0	0	2.5	2.7476663470054308	ADRB1
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)	8/263	0.336987665888831	1.0	0	0	1.2167300380228137	1.3234481509182887	NR6A1;AKR1B1;FOSB;MYBL2;GRHL1;ASCL2;ATF3;TBX3
calcium-dependent phospholipid binding (GO:0005544)	2/48	0.3383532866029959	1.0	0	0	1.6666666666666665	1.8061078378867632	ANXA3;SYT7
flavin adenine dinucleotide binding (GO:0050660)	2/49	0.3474929610282407	1.0	0	0	1.6326530612244896	1.7257320330061812	NOS3;KMO
acetylgalactosaminyltransferase activity (GO:0008376)	2/49	0.3474929610282407	1.0	0	0	1.6326530612244896	1.7257320330061812	B3GNT5;B3GNT3
inorganic anion transmembrane transporter activity (GO:0015103)	2/49	0.3474929610282407	1.0	0	0	1.6326530612244896	1.7257320330061812	SLC26A2;SLC26A6
protein tyrosine kinase binding (GO:1990782)	2/49	0.3474929610282407	1.0	0	0	1.6326530612244896	1.7257320330061812	TRIM6;ANGPT2
protein heterodimerization activity (GO:0046982)	8/266	0.3482442642625233	1.0	0	0	1.2030075187969924	1.2689938485775396	TENM3;SCUBE1;HEXB;AGTR1;PPARG;ADRB1;ATF3;MPP7
proton-transporting ATPase activity, rotational mechanism (GO:0046961)	1/17	0.3498657220916832	1.0	0	0	2.352941176470588	2.4710725865370216	ATP6V1C2
cholesterol transporter activity (GO:0017127)	1/17	0.3498657220916832	1.0	0	0	2.352941176470588	2.4710725865370216	ABCG2
antiporter activity (GO:0015297)	1/17	0.3498657220916832	1.0	0	0	2.352941176470588	2.4710725865370216	SLC7A5
GTP-Rho binding (GO:0017049)	1/17	0.3498657220916832	1.0	0	0	2.352941176470588	2.4710725865370216	STXBP6
ephrin receptor activity (GO:0005003)	1/17	0.3498657220916832	1.0	0	0	2.352941176470588	2.4710725865370216	EPHB3
DNA binding, bending (GO:0008301)	1/17	0.3498657220916832	1.0	0	0	2.352941176470588	2.4710725865370216	HMGB3
metalloaminopeptidase activity (GO:0070006)	1/17	0.3498657220916832	1.0	0	0	2.352941176470588	2.4710725865370216	MMP15
transmembrane-ephrin receptor activity (GO:0005005)	1/17	0.3498657220916832	1.0	0	0	2.352941176470588	2.4710725865370216	EPHB3
G-protein coupled receptor activity (GO:0004930)	8/268	0.3557760110805534	1.0	0	0	1.1940298507462686	1.2339748400076258	P2RY6;OPN3;GPR78;FRZB;ADGRG6;CCR7;ACKR2;GPR157
microfilament motor activity (GO:0000146)	1/18	0.3661328787804519	1.0	0	0	2.222222222222222	2.232797677094987	MYO7A
Ran GTPase binding (GO:0008536)	1/18	0.3661328787804519	1.0	0	0	2.222222222222222	2.232797677094987	BIRC5
fatty acid ligase activity (GO:0015645)	1/18	0.3661328787804519	1.0	0	0	2.222222222222222	2.232797677094987	SLC27A2
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding (GO:0001205)	1/18	0.3661328787804519	1.0	0	0	2.222222222222222	2.232797677094987	HMGA1
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor (GO:0016646)	1/18	0.3661328787804519	1.0	0	0	2.222222222222222	2.232797677094987	ALDH4A1
transforming growth factor beta binding (GO:0050431)	1/19	0.3819938041881401	1.0	0	0	2.1052631578947367	2.0260018734944683	ENG
gamma-tubulin binding (GO:0043015)	1/19	0.3819938041881401	1.0	0	0	2.1052631578947367	2.0260018734944683	RAB11FIP5
protein kinase A regulatory subunit binding (GO:0034237)	1/19	0.3819938041881401	1.0	0	0	2.1052631578947367	2.0260018734944683	EZR
insulin receptor binding (GO:0005158)	1/19	0.3819938041881401	1.0	0	0	2.1052631578947367	2.0260018734944683	IGF2
intramolecular oxidoreductase activity, transposing S-S bonds (GO:0016864)	1/20	0.39745862307532415	1.0	0	0	2.0	1.8453288863961157	QSOX1
aldo-keto reductase (NADP) activity (GO:0004033)	1/20	0.39745862307532415	1.0	0	0	2.0	1.8453288863961157	AKR1B1
leak channel activity (GO:0022840)	1/20	0.39745862307532415	1.0	0	0	2.0	1.8453288863961157	KCNK5
protein disulfide isomerase activity (GO:0003756)	1/20	0.39745862307532415	1.0	0	0	2.0	1.8453288863961157	QSOX1
ubiquitin conjugating enzyme activity (GO:0061631)	1/20	0.39745862307532415	1.0	0	0	2.0	1.8453288863961157	UBE2C
alcohol dehydrogenase (NADP+) activity (GO:0008106)	1/20	0.39745862307532415	1.0	0	0	2.0	1.8453288863961157	AKR1B1
phospholipid-translocating ATPase activity (GO:0004012)	1/20	0.39745862307532415	1.0	0	0	2.0	1.8453288863961157	ABCB1
protein homodimerization activity (GO:0042803)	18/665	0.39878453658565316	1.0	0	0	1.0827067669172932	0.9953691607290224	CEBPA;CADM3;TENM3;HPGD;TFRC;SMAGP;HEXB;GRHL1;NR6A1;STK26;STC2;KYNU;SLIT2;NECTIN4;NECTIN3;ATF3;RAB11FIP4;ABCG2
metalloexopeptidase activity (GO:0008235)	2/55	0.40132045183103177	1.0	0	0	1.4545454545454544	1.3279927840918175	CPM;MMP15
SH3 domain binding (GO:0017124)	2/56	0.41009437639646396	1.0	0	0	1.4285714285714284	1.273382799199648	NCF1;ADAM12
protein kinase activator activity (GO:0030295)	2/56	0.41009437639646396	1.0	0	0	1.4285714285714284	1.273382799199648	CDKN1A;IGF2
sialyltransferase activity (GO:0008373)	1/21	0.41253720829731133	1.0	0	0	1.9047619047619047	1.6865311911285241	ST3GAL4
transcription factor activity, RNA polymerase II core promoter sequence-specific (GO:0000983)	1/21	0.41253720829731133	1.0	0	0	1.9047619047619047	1.6865311911285241	HEY1
hydrogen-exporting ATPase activity (GO:0036442)	1/21	0.41253720829731133	1.0	0	0	1.9047619047619047	1.6865311911285241	ATP6V1C2
ubiquitin-like protein conjugating enzyme activity (GO:0061650)	1/21	0.41253720829731133	1.0	0	0	1.9047619047619047	1.6865311911285241	UBE2C
Rab GTPase binding (GO:0017137)	4/131	0.4150802160785926	1.0	0	0	1.2213740458015265	1.0739340283044132	UNC13D;RAB11FIP4;EXPH5;RAB11FIP5
transition metal ion binding (GO:0046914)	11/400	0.4169157109422989	1.0	0	0	1.0999999999999999	0.9623583306123868	ATP7B;CA2;NOS3;SCD;FDX1;SIAH1;TET1;ZNF117;PPARG;TK1;S100A9
serine-type endopeptidase inhibitor activity (GO:0004867)	2/57	0.41880475936093825	1.0	0	0	1.4035087719298245	1.2215444712550116	SERPINE2;FURIN
ATPase activity, coupled to movement of substances (GO:0043492)	2/57	0.41880475936093825	1.0	0	0	1.4035087719298245	1.2215444712550116	ABCB1;ABCG2
ATPase activity, coupled (GO:0042623)	3/95	0.42520717958043197	1.0	0	0	1.263157894736842	1.0802257862809745	CDK7;RAD51;FIGN
actinin binding (GO:0042805)	1/22	0.42723918724304594	1.0	0	0	1.8181818181818181	1.5462023001914358	PPARG
Wnt-activated receptor activity (GO:0042813)	1/22	0.42723918724304594	1.0	0	0	1.8181818181818181	1.5462023001914358	FRZB
mRNA 5'-UTR binding (GO:0048027)	1/22	0.42723918724304594	1.0	0	0	1.8181818181818181	1.5462023001914358	IGF2BP2
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (GO:0016702)	1/22	0.42723918724304594	1.0	0	0	1.8181818181818181	1.5462023001914358	CDO1
NAD binding (GO:0051287)	1/22	0.42723918724304594	1.0	0	0	1.8181818181818181	1.5462023001914358	HPGD
core promoter proximal region DNA binding (GO:0001159)	1/22	0.42723918724304594	1.0	0	0	1.8181818181818181	1.5462023001914358	GATA3
zinc ion transmembrane transporter activity (GO:0005385)	1/22	0.42723918724304594	1.0	0	0	1.8181818181818181	1.5462023001914358	SLC39A8
telomerase RNA binding (GO:0070034)	1/22	0.42723918724304594	1.0	0	0	1.8181818181818181	1.5462023001914358	DCP2
metal ion binding (GO:0046872)	12/443	0.42985514611481473	1.0	0	0	1.0835214446952595	0.9148247366662601	MELK;SCUBE1;SCIN;SELL;STK26;CDC42BPG;MAN1C1;LRP2;SLIT2;S100A9;SYT7;CD320
protein phosphatase inhibitor activity (GO:0004864)	1/23	0.4415739476417069	1.0	0	0	1.7391304347826086	1.4215822280628116	PPP1R14C
disordered domain specific binding (GO:0097718)	1/23	0.4415739476417069	1.0	0	0	1.7391304347826086	1.4215822280628116	FN1
fibroblast growth factor binding (GO:0017134)	1/23	0.4415739476417069	1.0	0	0	1.7391304347826086	1.4215822280628116	FGFR4
Rho guanyl-nucleotide exchange factor activity (GO:0005089)	2/60	0.4445323414545099	1.0	0	0	1.3333333333333333	1.0809766233296643	VAV3;EPS8L1
kinase inhibitor activity (GO:0019210)	2/60	0.4445323414545099	1.0	0	0	1.3333333333333333	1.0809766233296643	CDKN1C;CDKN1A
double-stranded RNA binding (GO:0003725)	2/60	0.4445323414545099	1.0	0	0	1.3333333333333333	1.0809766233296643	TFRC;SLC3A2
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001077)	5/176	0.45010383602758924	1.0	0	0	1.1363636363636362	0.9071329273951444	TFAP2C;AKR1B1;MYBL2;GRHL1;ZNF750
protein serine/threonine phosphatase activity (GO:0004722)	2/62	0.46132803795917154	1.0	0	0	1.2903225806451613	0.9982527870331739	DUSP4;MTMR4
transferase activity, transferring hexosyl groups (GO:0016758)	3/101	0.4646041358021239	1.0	0	0	1.188118811881188	0.9107757110849387	HEXB;B3GNT5;B3GNT3
endoribonuclease activity, producing 5'-phosphomonoesters (GO:0016891)	1/25	0.4691782022031496	1.0	0	0	1.5999999999999999	1.2108361930392557	EXO1
protein tyrosine phosphatase activity (GO:0004725)	2/63	0.46961389196045544	1.0	0	0	1.2698412698412698	0.9598024487193709	DUSP4;PTPRF
PDZ domain binding (GO:0030165)	2/63	0.46961389196045544	1.0	0	0	1.2698412698412698	0.9598024487193709	ADRB1;SLC26A6
anion transmembrane transporter activity (GO:0008509)	2/63	0.46961389196045544	1.0	0	0	1.2698412698412698	0.9598024487193709	SLC26A2;SLC26A6
kinase binding (GO:0019900)	11/419	0.4775065367863742	1.0	0	0	1.0501193317422435	0.7762245083580811	CCNA2;CEBPA;ERRFI1;CDKN1A;TRIM6;CCNB1;SNAI1;FAM83D;CDC25A;RHOBTB1;AURKB
ATPase binding (GO:0051117)	2/64	0.47782308073315993	1.0	0	0	1.25	0.9231434237408449	AKR1B1;EZR
metal ion transmembrane transporter activity (GO:0046873)	1/26	0.4824653272482855	1.0	0	0	1.5384615384615385	1.1213018790930922	TUSC3
triglyceride lipase activity (GO:0004806)	1/26	0.4824653272482855	1.0	0	0	1.5384615384615385	1.1213018790930922	LIPG
exoribonuclease activity, producing 5'-phosphomonoesters (GO:0016896)	1/26	0.4824653272482855	1.0	0	0	1.5384615384615385	1.1213018790930922	DCP2
ATPase activity, coupled to transmembrane movement of ions, rotational mechanism (GO:0044769)	1/26	0.4824653272482855	1.0	0	0	1.5384615384615385	1.1213018790930922	ATP6V1C2
enhancer sequence-specific DNA binding (GO:0001158)	2/65	0.48595425402499	1.0	0	0	1.2307692307692308	0.8881732763477085	HMGA1;GATA2
Ras GTPase binding (GO:0017016)	5/185	0.4934514236492427	1.0	0	0	1.0810810810810811	0.7636009267838663	BIRC5;UNC13D;RAB11FIP4;EXPH5;RAB11FIP5
cysteine-type peptidase activity (GO:0008234)	2/66	0.49400617659427287	1.0	0	0	1.2121212121212122	0.8547966771455834	TINAGL1;CTSV
alpha-tubulin binding (GO:0043014)	1/27	0.49542050679657673	1.0	0	0	1.4814814814814814	1.0405161012766946	BEX4
calmodulin-dependent protein kinase activity (GO:0004683)	1/28	0.5080520173426427	1.0	0	0	1.4285714285714284	0.9673877718600257	PNCK
substrate-specific channel activity (GO:0022838)	1/28	0.5080520173426427	1.0	0	0	1.4285714285714284	0.9673877718600257	TRPV6
protein kinase inhibitor activity (GO:0004860)	2/68	0.5098678748711668	1.0	0	0	1.176470588235294	0.7924748890682	CDKN1C;CDKN1A
activating transcription factor binding (GO:0033613)	2/69	0.5176757123539347	1.0	0	0	1.1594202898550725	0.7633695892092621	PPARG;TBX3
sterol transporter activity (GO:0015248)	1/29	0.5203679297086519	1.0	0	0	1.379310344827586	0.9009919454829998	ABCG2
inorganic anion exchanger activity (GO:0005452)	1/29	0.5203679297086519	1.0	0	0	1.379310344827586	0.9009919454829998	SLC26A6
metallocarboxypeptidase activity (GO:0004181)	1/29	0.5203679297086519	1.0	0	0	1.379310344827586	0.9009919454829998	CPM
kinesin binding (GO:0019894)	1/29	0.5203679297086519	1.0	0	0	1.379310344827586	0.9009919454829998	FAM83D
sequence-specific DNA binding (GO:0043565)	10/395	0.5288275252987055	1.0	0	0	1.0126582278481011	0.645157407006616	NR6A1;MSX2;MAFF;PPARG;MAFK;MYBL2;FOXO4;GRHL1;TBX3;TEAD3
endopeptidase activity (GO:0004175)	9/355	0.5302762597473659	1.0	0	0	1.0140845070422535	0.6432917713661455	MMP11;TINAGL1;MMP15;HTRA4;FURIN;PRSS8;CTSV;PCSK6;TRABD2A
delayed rectifier potassium channel activity (GO:0005251)	1/30	0.5323761135569396	1.0	0	0	1.3333333333333333	0.8405400787509358	KCNS3
alpha-actinin binding (GO:0051393)	1/30	0.5323761135569396	1.0	0	0	1.3333333333333333	0.8405400787509358	PPARG
cation-transporting ATPase activity (GO:0019829)	1/30	0.5323761135569396	1.0	0	0	1.3333333333333333	0.8405400787509358	ATP7B
phosphotyrosine residue binding (GO:0001784)	1/30	0.5323761135569396	1.0	0	0	1.3333333333333333	0.8405400787509358	RASA1
organic anion transmembrane transporter activity (GO:0008514)	2/71	0.533041249161984	1.0	0	0	1.1267605633802817	0.7089086955075764	SLC26A2;SLC26A6
GTPase regulator activity (GO:0030695)	7/276	0.5379371670140033	1.0	0	0	1.0144927536231885	0.6289992187019386	VAV3;ERRFI1;SYDE1;DEPDC1B;RASA1;FAM13A;SLIT2
sodium ion transmembrane transporter activity (GO:0015081)	2/72	0.5405975770602098	1.0	0	0	1.111111111111111	0.6834223634393684	SLC13A4;SLC3A2
nucleobase-containing compound kinase activity (GO:0019205)	1/31	0.5440842429149877	1.0	0	0	1.2903225806451613	0.7853563687947012	TK1
phospholipase A2 activity (GO:0004623)	1/31	0.5440842429149877	1.0	0	0	1.2903225806451613	0.7853563687947012	PLBD1
glutathione transferase activity (GO:0004364)	1/31	0.5440842429149877	1.0	0	0	1.2903225806451613	0.7853563687947012	PTGES
deoxyribonuclease activity (GO:0004536)	1/31	0.5440842429149877	1.0	0	0	1.2903225806451613	0.7853563687947012	RAD51
DNA-dependent ATPase activity (GO:0008094)	2/73	0.548068839980631	1.0	0	0	1.095890410958904	0.6590184981053064	CDK7;RAD51
Rho GTPase binding (GO:0017048)	2/73	0.548068839980631	1.0	0	0	1.095890410958904	0.6590184981053064	PAK6;STXBP6
cytokine activity (GO:0005125)	4/156	0.5497287550278442	1.0	0	0	1.0256410256410255	0.6136720975199073	TGFB1;GDF15;INHBA;INHA
ATP-dependent microtubule motor activity, plus-end-directed (GO:0008574)	1/32	0.5554998006860319	1.0	0	0	1.25	0.7348587858794243	KIF17
phosphatidylinositol-3,4,5-trisphosphate binding (GO:0005547)	1/33	0.5666300836000462	1.0	0	0	1.2121212121212122	0.6885437552033686	CYTH3
protease binding (GO:0002020)	3/119	0.5746232085417885	1.0	0	0	1.0084033613445378	0.5586965470319281	SELL;FN1;FURIN
thiol-dependent ubiquitin-specific protease activity (GO:0004843)	2/77	0.5770948361053473	1.0	0	0	1.0389610389610389	0.571167444479923	OTUB2;USP27X
ion channel inhibitor activity (GO:0008200)	1/34	0.5774822066735724	1.0	0	0	1.176470588235294	0.6459737035478923	RASA1
aminopeptidase activity (GO:0004177)	1/35	0.5880631079793313	1.0	0	0	1.1428571428571428	0.6067668689681428	MMP15
protein phosphorylated amino acid binding (GO:0045309)	1/35	0.5880631079793313	1.0	0	0	1.1428571428571428	0.6067668689681428	RASA1
GTPase activator activity (GO:0005096)	6/250	0.5972232171805372	1.0	0	0	0.96	0.49484576385328055	VAV3;ERRFI1;SYDE1;DEPDC1B;RASA1;FAM13A
ion transmembrane transporter activity (GO:0015075)	1/36	0.5983795526602211	1.0	0	0	1.111111111111111	0.5705889143615132	TRPV6
exonuclease activity (GO:0004527)	1/37	0.6084381377362886	1.0	0	0	1.0810810810810811	0.5371459840670496	EXO1
snRNA binding (GO:0017069)	1/37	0.6084381377362886	1.0	0	0	1.0810810810810811	0.5371459840670496	HEXIM1
endopeptidase regulator activity (GO:0061135)	1/37	0.6084381377362886	1.0	0	0	1.0810810810810811	0.5371459840670496	TFPI
cysteine-type endopeptidase activity (GO:0004197)	2/82	0.611427375574375	1.0	0	0	0.975609756097561	0.4799600929754372	TINAGL1;CTSV
frizzled binding (GO:0005109)	1/38	0.6182452955593541	1.0	0	0	1.0526315789473684	0.5061789283103968	BAMBI
potassium ion transmembrane transporter activity (GO:0015079)	1/39	0.6278072988155387	1.0	0	0	1.0256410256410255	0.4774584703811021	KCNK5
CCR chemokine receptor binding (GO:0048020)	1/39	0.6278072988155387	1.0	0	0	1.0256410256410255	0.4774584703811021	CCRL2
receptor tyrosine kinase binding (GO:0030971)	1/40	0.6371302636481142	1.0	0	0	1.0	0.4507811487933908	ANGPT2
amino acid binding (GO:0016597)	1/40	0.6371302636481142	1.0	0	0	1.0	0.4507811487933908	NOS3
carboxypeptidase activity (GO:0004180)	1/40	0.6371302636481142	1.0	0	0	1.0	0.4507811487933908	CPM
motor activity (GO:0003774)	2/86	0.6373322377682995	1.0	0	0	0.9302325581395349	0.4190364586262058	MYO7A;KIF17
histone deacetylase binding (GO:0042826)	2/86	0.6373322377682995	1.0	0	0	0.9302325581395349	0.4190364586262058	BEX4;HDAC5
histone deacetylase activity (GO:0004407)	1/41	0.6462201541186453	1.0	0	0	0.975609756097561	0.42596589015410175	HDAC5
single-stranded DNA binding (GO:0003697)	2/88	0.649768200720319	1.0	0	0	0.9090909090909091	0.3919450854280717	RAD51;MCM10
serine-type peptidase activity (GO:0008236)	5/221	0.650657506006534	1.0	0	0	0.9049773755656108	0.388933827746351	MMP11;FURIN;PRSS8;CTSV;PCSK6
copper ion binding (GO:0005507)	1/42	0.6550827855909762	1.0	0	0	0.9523809523809523	0.4028511058268805	ATP7B
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616)	2/89	0.6558581466108996	1.0	0	0	0.898876404494382	0.37915573334263386	HPGD;PHGDH
GTPase activity (GO:0003924)	5/223	0.6584331039863255	1.0	0	0	0.8968609865470851	0.374791346581744	RAB3B;RAB15;RASA1;RAB38;RHOBTB1
transferase activity, transferring pentosyl groups (GO:0016763)	1/43	0.6637238288168202	1.0	0	0	0.9302325581395349	0.38129221998251456	UPP1
protein deacetylase activity (GO:0033558)	1/43	0.6637238288168202	1.0	0	0	0.9302325581395349	0.38129221998251456	HDAC5
lipase activity (GO:0016298)	1/44	0.6721488131969349	1.0	0	0	0.9090909090909091	0.3611595588775441	LIPG
non-membrane spanning protein tyrosine kinase activity (GO:0004715)	1/44	0.6721488131969349	1.0	0	0	0.9090909090909091	0.3611595588775441	MELK
Rac GTPase binding (GO:0048365)	1/44	0.6721488131969349	1.0	0	0	0.9090909090909091	0.3611595588775441	PAK6
cholesterol binding (GO:0015485)	1/44	0.6721488131969349	1.0	0	0	0.9090909090909091	0.3611595588775441	PROM2
thiol-dependent ubiquitinyl hydrolase activity (GO:0036459)	2/93	0.6793739096257446	1.0	0	0	0.8602150537634409	0.33254505468787643	OTUB2;USP27X
hydro-lyase activity (GO:0016836)	1/46	0.688372038071095	1.0	0	0	0.8695652173913043	0.32471811668930733	CA2
myosin binding (GO:0017022)	1/47	0.69618066242957	1.0	0	0	0.8510638297872339	0.30820942968045956	RAB3B
RNA polymerase II activating transcription factor binding (GO:0001102)	1/48	0.7037940023867141	1.0	0	0	0.8333333333333333	0.29272464657414204	TBX3
S-adenosylmethionine-dependent methyltransferase activity (GO:0008757)	1/48	0.7037940023867141	1.0	0	0	0.8333333333333333	0.29272464657414204	DNMT3B
ATP-dependent microtubule motor activity (GO:1990939)	1/49	0.7112169323217401	1.0	0	0	0.8163265306122448	0.27818594854238055	KIF17
sterol binding (GO:0032934)	1/49	0.7112169323217401	1.0	0	0	0.8163265306122448	0.27818594854238055	PROM2
chemokine receptor binding (GO:0042379)	1/50	0.7184542048692922	1.0	0	0	0.7999999999999999	0.26452265010260456	CCRL2
potassium channel activity (GO:0005267)	2/101	0.7224620897819041	1.0	0	0	0.792079207920792	0.2574972920889452	KCNK5;KCNS3
serine-type endopeptidase activity (GO:0004252)	4/197	0.7291779769722512	1.0	0	0	0.8121827411167512	0.256517716355367	MMP11;FURIN;CTSV;PCSK6
cysteine-type endopeptidase inhibitor activity (GO:0004869)	1/52	0.7323902008010184	1.0	0	0	0.7692307692307693	0.23957065064915506	BIRC5
hydrogen ion transmembrane transporter activity (GO:0015078)	1/52	0.7323902008010184	1.0	0	0	0.7692307692307693	0.23957065064915506	ATP6V1C2
GDP binding (GO:0019003)	1/52	0.7323902008010184	1.0	0	0	0.7692307692307693	0.23957065064915506	RAB3B
repressing transcription factor binding (GO:0070491)	1/54	0.7456376971972923	1.0	0	0	0.7407407407407407	0.21741885729120122	HDAC5
transcription corepressor activity (GO:0003714)	4/204	0.7537517055723526	1.0	0	0	0.7843137254901961	0.22171942600842715	THRB;PPP1R13L;DNMT3B;ATF3
protein kinase regulator activity (GO:0019887)	2/108	0.7560607182937743	1.0	0	0	0.7407407407407407	0.20713599320317938	CDKN1C;CDKN1A
G-protein coupled amine receptor activity (GO:0008227)	1/57	0.7642918118808011	1.0	0	0	0.7017543859649122	0.18863551580170362	ADRB1
transferase activity, transferring acyl groups other than amino-acyl groups (GO:0016747)	1/57	0.7642918118808011	1.0	0	0	0.7017543859649122	0.18863551580170362	PORCN
purine ribonucleoside binding (GO:0032550)	3/160	0.7667655416368673	1.0	0	0	0.7499999999999999	0.1991806550221081	RAB3B;RAB38;RHOBTB1
ATP binding (GO:0005524)	5/256	0.7702386089242694	1.0	0	0	0.78125	0.2039491643890629	ATP7B;RAD51;WNK2;STK26;CDC42BPG
zinc ion binding (GO:0008270)	6/303	0.7722215065865932	1.0	0	0	0.792079207920792	0.20473967879789728	CA2;SIAH1;ZNF117;PPARG;TK1;S100A9
nuclease activity (GO:0004518)	1/60	0.7815804178020295	1.0	0	0	0.6666666666666666	0.1642914883710904	EXO1
microtubule motor activity (GO:0003777)	1/61	0.787057299393142	1.0	0	0	0.6557377049180327	0.15701916449443715	KIF17
ubiquitin binding (GO:0043130)	1/63	0.7976032864598676	1.0	0	0	0.6349206349206349	0.143583453909114	OTUB2
small GTPase binding (GO:0031267)	1/64	0.8026791537609369	1.0	0	0	0.625	0.13737512770713134	RAB11FIP4
mRNA 3'-UTR binding (GO:0003730)	1/64	0.8026791537609369	1.0	0	0	0.625	0.13737512770713134	IGF2BP2
guanyl ribonucleotide binding (GO:0032561)	3/171	0.8043668655403171	1.0	0	0	0.7017543859649122	0.15277179891457604	RAB3B;RAB38;RHOBTB1
methyltransferase activity (GO:0008168)	1/68	0.8217434703815468	1.0	0	0	0.588235294117647	0.11548647791811906	DNMT3B
adenyl ribonucleotide binding (GO:0032559)	5/280	0.8323710018345482	1.0	0	0	0.7142857142857142	0.13105501563232108	ATP7B;RAD51;WNK2;STK26;CDC42BPG
magnesium ion binding (GO:0000287)	2/128	0.8333219827301188	1.0	0	0	0.625	0.11395948600660934	STK26;CDC42BPG
endonuclease activity (GO:0004519)	1/74	0.8469485510129866	1.0	0	0	0.5405405405405406	0.08979206961117422	RAD51
ubiquitin-like protein ligase activity (GO:0061659)	3/187	0.8498672951815496	1.0	0	0	0.6417112299465241	0.10439041604413632	TRIM6;UBE2C;SIAH1
ubiquitin-like protein-specific protease activity (GO:0019783)	1/75	0.8507890041924216	1.0	0	0	0.5333333333333333	0.08618193057063522	OTUB2
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (GO:0016811)	1/76	0.8545332771182171	1.0	0	0	0.5263157894736842	0.08273675463408255	HDAC5
GTPase binding (GO:0051020)	1/77	0.8581837738781999	1.0	0	0	0.5194805194805194	0.07944779935587648	RASA1
syntaxin binding (GO:0019905)	1/78	0.8617428383211508	1.0	0	0	0.5128205128205128	0.07630686371389282	SYT7
calcium ion transmembrane transporter activity (GO:0015085)	1/78	0.8617428383211508	1.0	0	0	0.5128205128205128	0.07630686371389282	TRPV6
ubiquitin protein ligase activity (GO:0061630)	3/193	0.8643970860607247	1.0	0	0	0.6217616580310881	0.09060498989180321	TRIM6;UBE2C;SIAH1
purine ribonucleoside triphosphate binding (GO:0035639)	7/397	0.870791330129559	1.0	0	0	0.7052896725440806	0.09757887568679574	ATP7B;RAD51;STK26;CDC42BPG;WNK2;RAB38;RHOBTB1
protein transporter activity (GO:0008565)	1/81	0.8718940108877108	1.0	0	0	0.49382716049382713	0.06769748622604009	LRP2
phosphatidylinositol phosphate binding (GO:1901981)	1/82	0.8751096392159449	1.0	0	0	0.4878048780487805	0.0650761456161355	CYTH3
cation channel activity (GO:0005261)	2/147	0.8855250425011134	1.0	0	0	0.5442176870748299	0.06616301579617412	KCNK5;TRPV6
voltage-gated potassium channel activity (GO:0005249)	1/86	0.8871864408298141	1.0	0	0	0.46511627906976744	0.055674477287034875	KCNS3
GTP binding (GO:0005525)	2/148	0.8878025668300037	1.0	0	0	0.5405405405405406	0.06432751100587912	RAB38;RHOBTB1
ubiquitin-protein transferase activity (GO:0004842)	7/418	0.9011200220441544	1.0	0	0	0.6698564593301435	0.06974332468962202	TRIM6;KLHL5;UBE2C;SIAH1;NEURL1;BIRC5;SKP2
growth factor receptor binding (GO:0070851)	1/93	0.9055837893531324	1.0	0	0	0.43010752688172044	0.04265611705062928	PGF
protein phosphatase binding (GO:0019903)	1/93	0.9055837893531324	1.0	0	0	0.43010752688172044	0.04265611705062928	MTMR4
calcium channel activity (GO:0005262)	1/94	0.9079551737327357	1.0	0	0	0.42553191489361697	0.041089476483082504	TRPV6
ion channel activity (GO:0005216)	1/94	0.9079551737327357	1.0	0	0	0.42553191489361697	0.041089476483082504	TRPV6
nucleoside-triphosphatase activity (GO:0017111)	7/425	0.9097869848534588	1.0	0	0	0.6588235294117647	0.062288331873903785	RAB3B;RAB15;RASA1;FIGN;RAB38;KIF17;RHOBTB1
voltage-gated cation channel activity (GO:0022843)	1/101	0.9229711233572102	1.0	0	0	0.396039603960396	0.03174547746753108	KCNS3
phosphatase binding (GO:0019902)	1/103	0.9267934783334831	1.0	0	0	0.38834951456310673	0.029524086681869306	MTMR4
ubiquitin-like protein ligase binding (GO:0044389)	4/298	0.9424112537037054	1.0	0	0	0.5369127516778524	0.03184618771539568	CDKN1A;CCNB1;UBE2C;DIO2
ATPase activity (GO:0016887)	2/204	0.9650279113932755	1.0	0	0	0.39215686274509803	0.013960099740326437	FIGN;KIF17
ubiquitin protein ligase binding (GO:0031625)	3/285	0.9750541279910789	1.0	0	0	0.42105263157894735	0.010636755215559447	CDKN1A;UBE2C;DIO2
mRNA binding (GO:0003729)	1/180	0.9897221313580854	1.0	0	0	0.2222222222222222	0.0022957890324634806	IGF2BP2
RNA binding (GO:0003723)	14/1388	0.9999838467456074	1.0	0	0	0.4034582132564841	6.517215792794732E-6	HEXIM1;DSP;TFRC;FAM46A;HMGB3;SLC3A2;KRT18;PEG10;IGF2BP2;MBNL3;EZR;SLC16A3;DCP2;HIST1H1C
